Some things never change -- the first depression in U.S. history was very similar to all future economic downturns, including today's.
The Panic of 1819 sparked a crisis that featured price drops, bank failures, mortgage foreclosures, and mass unemployment. The main culprit in the economic downturn was the Second Bank of the United States (forerunner to today’s Federal Reserve System). The Bank offered bad (and sometimes fraudulent) loans and printed paper money that fueled overspeculation and inflation.